Genetic Associations for Activated Partial Thromboplastin Time and Prothrombin Time, their Gene Expression Profiles, and Risk of Coronary Artery Disease
Identifieur interne : 005379 ( Main/Exploration ); précédent : 005378; suivant : 005380Genetic Associations for Activated Partial Thromboplastin Time and Prothrombin Time, their Gene Expression Profiles, and Risk of Coronary Artery Disease
Auteurs : Weihong Tang [États-Unis] ; Christine Schwienbacher [Italie] ; Lorna M. Lopez [Royaume-Uni] ; Yoav Ben-Shlomo [Royaume-Uni] ; Tiphaine Oudot-Mellakh [France] ; Andrew D. Johnson [États-Unis] ; Nilesh J. Samani [Royaume-Uni] ; Saonli Basu [États-Unis] ; Martin Gögele [Italie] ; Gail Davies [Royaume-Uni] ; Gordon D. O. Lowe [Royaume-Uni] ; David-Alexandre Tregouet [France] ; Adrian Tan [États-Unis] ; James S. Pankow [États-Unis] ; Albert Tenesa [Royaume-Uni] ; Daniel Levy [États-Unis] ; Claudia B. Volpato [Italie] ; Ann Rumley [Royaume-Uni] ; Alan J. Gow [Royaume-Uni] ; Cosetta Minelli [Italie] ; John W. G. Yarnell [Royaume-Uni] ; David J. Porteous [Royaume-Uni] ; John M. Starr [Royaume-Uni] ; John Gallacher [Royaume-Uni] ; Eric Boerwinkle [États-Unis] ; Peter M. Visscher [Australie] ; Peter P. Pramstaller [Italie, Allemagne] ; Mary Cushman [États-Unis] ; Valur Emilsson [États-Unis] ; Andrew S. Plump [États-Unis] ; Nena Matijevic [États-Unis] ; Pierre-Emmanuel Morange [France] ; Ian J. Deary [Royaume-Uni] ; Andrew A. Hicks [Italie] ; Aaron R. Folsom [États-Unis]Source :
- American Journal of Human Genetics [ 0002-9297 ] ; 2012.
Abstract
Activated partial thromboplastin time (aPTT) and prothrombin time (PT) are clinical tests commonly used to screen for coagulation-factor deficiencies. One genome-wide association study (GWAS) has been reported previously for aPTT, but no GWAS has been reported for PT. We conducted a GWAS and meta-analysis to identify genetic loci for aPTT and PT. The GWAS for aPTT was conducted in 9,240 individuals of European ancestry from the Atherosclerosis Risk in Communities (ARIC) study, and the GWAS for PT was conducted in 2,583 participants from the Genetic Study of Three Population Microisolates in South Tyrol (MICROS) and the Lothian Birth Cohorts (LBC) of 1921 and 1936. Replication was assessed in 1,041 to 3,467 individuals. For aPTT, previously reported associations with
Url:
DOI: 10.1016/j.ajhg.2012.05.009
PubMed: 22703881
PubMed Central: 3397273
Affiliations:
- Allemagne, Australie, France, Italie, Royaume-Uni, États-Unis
- Maryland, Massachusetts, Minnesota, New Jersey, Provence-Alpes-Côte d'Azur, Texas, Vermont, Écosse
- Glasgow, Marseille, Édimbourg
- Université d'Aix-Marseille, Université d'Édimbourg, Université de Glasgow
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Le document en format XML
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O." last="Lowe">Gordon D. O. Lowe</name><affiliation wicri:level="4"><nlm:aff id="aff14">Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Tregouet, David Alexandre" sort="Tregouet, David Alexandre" uniqKey="Tregouet D" first="David-Alexandre" last="Tregouet">David-Alexandre Tregouet</name><affiliation wicri:level="1"><nlm:aff id="aff7">INSERM UMR_S 937; Institute of Cardiometabolism and Nutrition (ICAN); Université Pierre et Marie Curie (UPMC, Paris 6); 75013 Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR_S 937; Institute of Cardiometabolism and Nutrition (ICAN); Université Pierre et Marie Curie (UPMC, Paris 6); 75013 Paris</wicri:regionArea><wicri:noRegion>75013 Paris</wicri:noRegion><wicri:noRegion>75013 Paris</wicri:noRegion></affiliation></author><author><name sortKey="Tan, Adrian" sort="Tan, Adrian" uniqKey="Tan A" first="Adrian" last="Tan">Adrian Tan</name><affiliation wicri:level="2"><nlm:aff id="aff13">Division of Biostatistics, University of Minnesota, Minneapolis, MN 55455, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Biostatistics, University of Minnesota, Minneapolis, MN 55455</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Pankow, James S" sort="Pankow, James S" uniqKey="Pankow J" first="James S." last="Pankow">James S. Pankow</name><affiliation wicri:level="2"><nlm:aff id="aff1">Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55454, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55454</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Tenesa, Albert" sort="Tenesa, Albert" uniqKey="Tenesa A" first="Albert" last="Tenesa">Albert Tenesa</name><affiliation wicri:level="1"><nlm:aff id="aff15">Institute of Genetics and Molecular Medicine, Medical Research Council (MRC) Human Genetics Unit, Edinburgh EH4 2XU, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Genetics and Molecular Medicine, Medical Research Council (MRC) Human Genetics Unit, Edinburgh EH4 2XU</wicri:regionArea><wicri:noRegion>Edinburgh EH4 2XU</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="aff16">The Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian EH25 9RG, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian EH25 9RG</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Levy, Daniel" sort="Levy, Daniel" uniqKey="Levy D" first="Daniel" last="Levy">Daniel Levy</name><affiliation wicri:level="2"><nlm:aff id="aff9">Center for Population Studies, National Heart, Lung and Blood Institute, Bethesda, MD 20824, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Population Studies, National Heart, Lung and Blood Institute, Bethesda, MD 20824</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Volpato, Claudia B" sort="Volpato, Claudia B" uniqKey="Volpato C" first="Claudia B." last="Volpato">Claudia B. Volpato</name><affiliation wicri:level="1"><nlm:aff id="aff2">Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC); affiliated institute of the University of Lübeck, Lübeck, Germany), Viale Druso 1, 39100 Bolzano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC); affiliated institute of the University of Lübeck, Lübeck, Germany), Viale Druso 1, 39100 Bolzano</wicri:regionArea><wicri:noRegion>39100 Bolzano</wicri:noRegion></affiliation></author><author><name sortKey="Rumley, Ann" sort="Rumley, Ann" uniqKey="Rumley A" first="Ann" last="Rumley">Ann Rumley</name><affiliation wicri:level="4"><nlm:aff id="aff14">Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Gow, Alan J" sort="Gow, Alan J" uniqKey="Gow A" first="Alan J." last="Gow">Alan J. Gow</name><affiliation wicri:level="4"><nlm:aff id="aff4">Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff5">Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Minelli, Cosetta" sort="Minelli, Cosetta" uniqKey="Minelli C" first="Cosetta" last="Minelli">Cosetta Minelli</name><affiliation wicri:level="1"><nlm:aff id="aff2">Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC); affiliated institute of the University of Lübeck, Lübeck, Germany), Viale Druso 1, 39100 Bolzano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC); affiliated institute of the University of Lübeck, Lübeck, Germany), Viale Druso 1, 39100 Bolzano</wicri:regionArea><wicri:noRegion>39100 Bolzano</wicri:noRegion></affiliation></author><author><name sortKey="Yarnell, John W G" sort="Yarnell, John W G" uniqKey="Yarnell J" first="John W. G." last="Yarnell">John W. G. Yarnell</name><affiliation wicri:level="1"><nlm:aff id="aff17">Epidemiology Research Group, Queen's University Belfast, Grosvenor Road, Belfast BT12 6BJ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Epidemiology Research Group, Queen's University Belfast, Grosvenor Road, Belfast BT12 6BJ</wicri:regionArea><wicri:noRegion>Belfast BT12 6BJ</wicri:noRegion></affiliation></author><author><name sortKey="Porteous, David J" sort="Porteous, David J" uniqKey="Porteous D" first="David J." last="Porteous">David J. Porteous</name><affiliation wicri:level="4"><nlm:aff id="aff4">Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff18">Medical Genetics Section, University of Edinburgh, Edinburgh EH4 2XU, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Genetics Section, University of Edinburgh, Edinburgh EH4 2XU</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Starr, John M" sort="Starr, John M" uniqKey="Starr J" first="John M." last="Starr">John M. Starr</name><affiliation wicri:level="4"><nlm:aff id="aff4">Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff19">Alzheimer Scotland Dementia Research Centre, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Alzheimer Scotland Dementia Research Centre, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Gallacher, John" sort="Gallacher, John" uniqKey="Gallacher J" first="John" last="Gallacher">John Gallacher</name><affiliation wicri:level="1"><nlm:aff id="aff20">Department of Primary Care and Public Health, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Primary Care and Public Health, School of Medicine, Cardiff University, Cardiff CF14 4XN</wicri:regionArea><wicri:noRegion>Cardiff CF14 4XN</wicri:noRegion></affiliation></author><author><name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name><affiliation wicri:level="2"><nlm:aff id="aff21">Human Genetics Center and Human Genome Sequencing Center, University of Texas Health Science Center at Houston, Houston, TX 77030, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Human Genetics Center and Human Genome Sequencing Center, University of Texas Health Science Center at Houston, Houston, TX 77030</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Visscher, Peter M" sort="Visscher, Peter M" uniqKey="Visscher P" first="Peter M." last="Visscher">Peter M. Visscher</name><affiliation wicri:level="1"><nlm:aff id="aff22">Queensland Statistical Genetics, Queensland Institute of Medical Research, Brisbane 4029, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Statistical Genetics, Queensland Institute of Medical Research, Brisbane 4029</wicri:regionArea><wicri:noRegion>Brisbane 4029</wicri:noRegion></affiliation></author><author><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P." last="Pramstaller">Peter P. Pramstaller</name><affiliation wicri:level="1"><nlm:aff id="aff2">Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC); affiliated institute of the University of Lübeck, Lübeck, Germany), Viale Druso 1, 39100 Bolzano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC); affiliated institute of the University of Lübeck, Lübeck, Germany), Viale Druso 1, 39100 Bolzano</wicri:regionArea><wicri:noRegion>39100 Bolzano</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff23">Department of Neurology, General Central Hospital, 39100 Bolzano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology, General Central Hospital, 39100 Bolzano</wicri:regionArea><wicri:noRegion>39100 Bolzano</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff24">Department of Neurology, University of Lübeck, 23538 Lübeck, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Lübeck, 23538 Lübeck</wicri:regionArea><wicri:noRegion>23538 Lübeck</wicri:noRegion><wicri:noRegion>23538 Lübeck</wicri:noRegion><wicri:noRegion>23538 Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Cushman, Mary" sort="Cushman, Mary" uniqKey="Cushman M" first="Mary" last="Cushman">Mary Cushman</name><affiliation wicri:level="2"><nlm:aff id="aff25">Departments of Medicine and Pathology, University of Vermont, Burlington, VT 05405, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Medicine and Pathology, University of Vermont, Burlington, VT 05405</wicri:regionArea><placeName><region type="state">Vermont</region></placeName></affiliation></author><author><name sortKey="Emilsson, Valur" sort="Emilsson, Valur" uniqKey="Emilsson V" first="Valur" last="Emilsson">Valur Emilsson</name><affiliation wicri:level="2"><nlm:aff id="aff26">Molecular Programming and Research Informatics, Merck & Co., Inc., Rahway, NJ 07065, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular Programming and Research Informatics, Merck & Co., Inc., Rahway, NJ 07065</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Plump, Andrew S" sort="Plump, Andrew S" uniqKey="Plump A" first="Andrew S." last="Plump">Andrew S. Plump</name><affiliation wicri:level="2"><nlm:aff id="aff27">Department of Cardiovascular Disease, Merck Research Laboratory, Rahway, NJ 07065, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cardiovascular Disease, Merck Research Laboratory, Rahway, NJ 07065</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Matijevic, Nena" sort="Matijevic, Nena" uniqKey="Matijevic N" first="Nena" last="Matijevic">Nena Matijevic</name><affiliation wicri:level="2"><nlm:aff id="aff28">Hemostasis Laboratory, University of Texas Health Science Center at Houston, Houston, TX 77030, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Hemostasis Laboratory, University of Texas Health Science Center at Houston, Houston, TX 77030</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Morange, Pierre Emmanuel" sort="Morange, Pierre Emmanuel" uniqKey="Morange P" first="Pierre-Emmanuel" last="Morange">Pierre-Emmanuel Morange</name><affiliation wicri:level="4"><nlm:aff id="aff29">INSERM, UMR_S 1062, Aix-Marseille Université, 13385 Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, UMR_S 1062, Aix-Marseille Université, 13385 Marseille</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J." last="Deary">Ian J. Deary</name><affiliation wicri:level="4"><nlm:aff id="aff4">Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff5">Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Hicks, Andrew A" sort="Hicks, Andrew A" uniqKey="Hicks A" first="Andrew A." last="Hicks">Andrew A. Hicks</name><affiliation wicri:level="1"><nlm:aff id="aff2">Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC); affiliated institute of the University of Lübeck, Lübeck, Germany), Viale Druso 1, 39100 Bolzano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC); affiliated institute of the University of Lübeck, Lübeck, Germany), Viale Druso 1, 39100 Bolzano</wicri:regionArea><wicri:noRegion>39100 Bolzano</wicri:noRegion></affiliation></author><author><name sortKey="Folsom, Aaron R" sort="Folsom, Aaron R" uniqKey="Folsom A" first="Aaron R." last="Folsom">Aaron R. Folsom</name><affiliation wicri:level="2"><nlm:aff id="aff1">Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55454, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55454</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22703881</idno><idno type="pmc">3397273</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397273</idno><idno type="RBID">PMC:3397273</idno><idno type="doi">10.1016/j.ajhg.2012.05.009</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">001199</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001199</idno><idno type="wicri:Area/Pmc/Curation">001060</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001060</idno><idno type="wicri:Area/Pmc/Checkpoint">001F34</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001F34</idno><idno type="wicri:Area/Ncbi/Merge">000E63</idno><idno type="wicri:Area/Ncbi/Curation">000E63</idno><idno type="wicri:Area/Ncbi/Checkpoint">000E63</idno><idno type="wicri:doubleKey">0002-9297:2012:Tang W:genetic:associations:for</idno><idno type="wicri:Area/Main/Merge">005618</idno><idno type="wicri:Area/Main/Curation">005379</idno><idno type="wicri:Area/Main/Exploration">005379</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genetic Associations for Activated Partial Thromboplastin Time and Prothrombin Time, their Gene Expression Profiles, and Risk of Coronary Artery Disease</title><author><name sortKey="Tang, Weihong" sort="Tang, Weihong" uniqKey="Tang W" first="Weihong" last="Tang">Weihong Tang</name><affiliation wicri:level="2"><nlm:aff id="aff1">Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55454, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55454</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Schwienbacher, Christine" sort="Schwienbacher, Christine" uniqKey="Schwienbacher C" first="Christine" last="Schwienbacher">Christine Schwienbacher</name><affiliation wicri:level="1"><nlm:aff id="aff2">Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC); affiliated institute of the University of Lübeck, Lübeck, Germany), Viale Druso 1, 39100 Bolzano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC); affiliated institute of the University of Lübeck, Lübeck, Germany), Viale Druso 1, 39100 Bolzano</wicri:regionArea><wicri:noRegion>39100 Bolzano</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Experimental and Diagnostic Medicine, University of Ferrara, 44121 Ferrara, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Experimental and Diagnostic Medicine, University of Ferrara, 44121 Ferrara</wicri:regionArea><wicri:noRegion>44121 Ferrara</wicri:noRegion></affiliation></author><author><name sortKey="Lopez, Lorna M" sort="Lopez, Lorna M" uniqKey="Lopez L" first="Lorna M." last="Lopez">Lorna M. Lopez</name><affiliation wicri:level="4"><nlm:aff id="aff4">Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff5">Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Ben Shlomo, Yoav" sort="Ben Shlomo, Yoav" uniqKey="Ben Shlomo Y" first="Yoav" last="Ben-Shlomo">Yoav Ben-Shlomo</name><affiliation wicri:level="1"><nlm:aff id="aff6">School of Social and Community Medicine, University of Bristol, Bristol BS8 2PS, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Social and Community Medicine, University of Bristol, Bristol BS8 2PS</wicri:regionArea><wicri:noRegion>Bristol BS8 2PS</wicri:noRegion></affiliation></author><author><name sortKey="Oudot Mellakh, Tiphaine" sort="Oudot Mellakh, Tiphaine" uniqKey="Oudot Mellakh T" first="Tiphaine" last="Oudot-Mellakh">Tiphaine Oudot-Mellakh</name><affiliation wicri:level="1"><nlm:aff id="aff7">INSERM UMR_S 937; Institute of Cardiometabolism and Nutrition (ICAN); Université Pierre et Marie Curie (UPMC, Paris 6); 75013 Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR_S 937; Institute of Cardiometabolism and Nutrition (ICAN); Université Pierre et Marie Curie (UPMC, Paris 6); 75013 Paris</wicri:regionArea><wicri:noRegion>75013 Paris</wicri:noRegion><wicri:noRegion>75013 Paris</wicri:noRegion></affiliation></author><author><name sortKey="Johnson, Andrew D" sort="Johnson, Andrew D" uniqKey="Johnson A" first="Andrew D." last="Johnson">Andrew D. Johnson</name><affiliation wicri:level="2"><nlm:aff id="aff8">National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA 01702, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA 01702</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff9">Center for Population Studies, National Heart, Lung and Blood Institute, Bethesda, MD 20824, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Population Studies, National Heart, Lung and Blood Institute, Bethesda, MD 20824</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff10">Division of Intramural Research, National Heart, Lung and Blood Institute, Bethesda, MD 20824, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Intramural Research, National Heart, Lung and Blood Institute, Bethesda, MD 20824</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Samani, Nilesh J" sort="Samani, Nilesh J" uniqKey="Samani N" first="Nilesh J." last="Samani">Nilesh J. Samani</name><affiliation wicri:level="1"><nlm:aff id="aff11">Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield Hospital, Leicester LE3 9QP, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield Hospital, Leicester LE3 9QP</wicri:regionArea><wicri:noRegion>Leicester LE3 9QP</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff12">National Institute for Health Research Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Institute for Health Research Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP</wicri:regionArea><wicri:noRegion>Leicester LE3 9QP</wicri:noRegion></affiliation></author><author><name sortKey="Basu, Saonli" sort="Basu, Saonli" uniqKey="Basu S" first="Saonli" last="Basu">Saonli Basu</name><affiliation wicri:level="2"><nlm:aff id="aff13">Division of Biostatistics, University of Minnesota, Minneapolis, MN 55455, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Biostatistics, University of Minnesota, Minneapolis, MN 55455</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Gogele, Martin" sort="Gogele, Martin" uniqKey="Gogele M" first="Martin" last="Gögele">Martin Gögele</name><affiliation wicri:level="1"><nlm:aff id="aff2">Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC); affiliated institute of the University of Lübeck, Lübeck, Germany), Viale Druso 1, 39100 Bolzano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC); affiliated institute of the University of Lübeck, Lübeck, Germany), Viale Druso 1, 39100 Bolzano</wicri:regionArea><wicri:noRegion>39100 Bolzano</wicri:noRegion></affiliation></author><author><name sortKey="Davies, Gail" sort="Davies, Gail" uniqKey="Davies G" first="Gail" last="Davies">Gail Davies</name><affiliation wicri:level="4"><nlm:aff id="aff5">Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Lowe, Gordon D O" sort="Lowe, Gordon D O" uniqKey="Lowe G" first="Gordon D. O." last="Lowe">Gordon D. O. Lowe</name><affiliation wicri:level="4"><nlm:aff id="aff14">Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Tregouet, David Alexandre" sort="Tregouet, David Alexandre" uniqKey="Tregouet D" first="David-Alexandre" last="Tregouet">David-Alexandre Tregouet</name><affiliation wicri:level="1"><nlm:aff id="aff7">INSERM UMR_S 937; Institute of Cardiometabolism and Nutrition (ICAN); Université Pierre et Marie Curie (UPMC, Paris 6); 75013 Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR_S 937; Institute of Cardiometabolism and Nutrition (ICAN); Université Pierre et Marie Curie (UPMC, Paris 6); 75013 Paris</wicri:regionArea><wicri:noRegion>75013 Paris</wicri:noRegion><wicri:noRegion>75013 Paris</wicri:noRegion></affiliation></author><author><name sortKey="Tan, Adrian" sort="Tan, Adrian" uniqKey="Tan A" first="Adrian" last="Tan">Adrian Tan</name><affiliation wicri:level="2"><nlm:aff id="aff13">Division of Biostatistics, University of Minnesota, Minneapolis, MN 55455, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Biostatistics, University of Minnesota, Minneapolis, MN 55455</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Pankow, James S" sort="Pankow, James S" uniqKey="Pankow J" first="James S." last="Pankow">James S. Pankow</name><affiliation wicri:level="2"><nlm:aff id="aff1">Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55454, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55454</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Tenesa, Albert" sort="Tenesa, Albert" uniqKey="Tenesa A" first="Albert" last="Tenesa">Albert Tenesa</name><affiliation wicri:level="1"><nlm:aff id="aff15">Institute of Genetics and Molecular Medicine, Medical Research Council (MRC) Human Genetics Unit, Edinburgh EH4 2XU, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Genetics and Molecular Medicine, Medical Research Council (MRC) Human Genetics Unit, Edinburgh EH4 2XU</wicri:regionArea><wicri:noRegion>Edinburgh EH4 2XU</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="aff16">The Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian EH25 9RG, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian EH25 9RG</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Levy, Daniel" sort="Levy, Daniel" uniqKey="Levy D" first="Daniel" last="Levy">Daniel Levy</name><affiliation wicri:level="2"><nlm:aff id="aff9">Center for Population Studies, National Heart, Lung and Blood Institute, Bethesda, MD 20824, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Population Studies, National Heart, Lung and Blood Institute, Bethesda, MD 20824</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Volpato, Claudia B" sort="Volpato, Claudia B" uniqKey="Volpato C" first="Claudia B." last="Volpato">Claudia B. Volpato</name><affiliation wicri:level="1"><nlm:aff id="aff2">Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC); affiliated institute of the University of Lübeck, Lübeck, Germany), Viale Druso 1, 39100 Bolzano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC); affiliated institute of the University of Lübeck, Lübeck, Germany), Viale Druso 1, 39100 Bolzano</wicri:regionArea><wicri:noRegion>39100 Bolzano</wicri:noRegion></affiliation></author><author><name sortKey="Rumley, Ann" sort="Rumley, Ann" uniqKey="Rumley A" first="Ann" last="Rumley">Ann Rumley</name><affiliation wicri:level="4"><nlm:aff id="aff14">Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Gow, Alan J" sort="Gow, Alan J" uniqKey="Gow A" first="Alan J." last="Gow">Alan J. Gow</name><affiliation wicri:level="4"><nlm:aff id="aff4">Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff5">Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Minelli, Cosetta" sort="Minelli, Cosetta" uniqKey="Minelli C" first="Cosetta" last="Minelli">Cosetta Minelli</name><affiliation wicri:level="1"><nlm:aff id="aff2">Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC); affiliated institute of the University of Lübeck, Lübeck, Germany), Viale Druso 1, 39100 Bolzano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC); affiliated institute of the University of Lübeck, Lübeck, Germany), Viale Druso 1, 39100 Bolzano</wicri:regionArea><wicri:noRegion>39100 Bolzano</wicri:noRegion></affiliation></author><author><name sortKey="Yarnell, John W G" sort="Yarnell, John W G" uniqKey="Yarnell J" first="John W. G." last="Yarnell">John W. G. Yarnell</name><affiliation wicri:level="1"><nlm:aff id="aff17">Epidemiology Research Group, Queen's University Belfast, Grosvenor Road, Belfast BT12 6BJ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Epidemiology Research Group, Queen's University Belfast, Grosvenor Road, Belfast BT12 6BJ</wicri:regionArea><wicri:noRegion>Belfast BT12 6BJ</wicri:noRegion></affiliation></author><author><name sortKey="Porteous, David J" sort="Porteous, David J" uniqKey="Porteous D" first="David J." last="Porteous">David J. Porteous</name><affiliation wicri:level="4"><nlm:aff id="aff4">Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff18">Medical Genetics Section, University of Edinburgh, Edinburgh EH4 2XU, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Genetics Section, University of Edinburgh, Edinburgh EH4 2XU</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Starr, John M" sort="Starr, John M" uniqKey="Starr J" first="John M." last="Starr">John M. Starr</name><affiliation wicri:level="4"><nlm:aff id="aff4">Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff19">Alzheimer Scotland Dementia Research Centre, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Alzheimer Scotland Dementia Research Centre, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Gallacher, John" sort="Gallacher, John" uniqKey="Gallacher J" first="John" last="Gallacher">John Gallacher</name><affiliation wicri:level="1"><nlm:aff id="aff20">Department of Primary Care and Public Health, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Primary Care and Public Health, School of Medicine, Cardiff University, Cardiff CF14 4XN</wicri:regionArea><wicri:noRegion>Cardiff CF14 4XN</wicri:noRegion></affiliation></author><author><name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name><affiliation wicri:level="2"><nlm:aff id="aff21">Human Genetics Center and Human Genome Sequencing Center, University of Texas Health Science Center at Houston, Houston, TX 77030, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Human Genetics Center and Human Genome Sequencing Center, University of Texas Health Science Center at Houston, Houston, TX 77030</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Visscher, Peter M" sort="Visscher, Peter M" uniqKey="Visscher P" first="Peter M." last="Visscher">Peter M. Visscher</name><affiliation wicri:level="1"><nlm:aff id="aff22">Queensland Statistical Genetics, Queensland Institute of Medical Research, Brisbane 4029, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Statistical Genetics, Queensland Institute of Medical Research, Brisbane 4029</wicri:regionArea><wicri:noRegion>Brisbane 4029</wicri:noRegion></affiliation></author><author><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P." last="Pramstaller">Peter P. Pramstaller</name><affiliation wicri:level="1"><nlm:aff id="aff2">Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC); affiliated institute of the University of Lübeck, Lübeck, Germany), Viale Druso 1, 39100 Bolzano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC); affiliated institute of the University of Lübeck, Lübeck, Germany), Viale Druso 1, 39100 Bolzano</wicri:regionArea><wicri:noRegion>39100 Bolzano</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff23">Department of Neurology, General Central Hospital, 39100 Bolzano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology, General Central Hospital, 39100 Bolzano</wicri:regionArea><wicri:noRegion>39100 Bolzano</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff24">Department of Neurology, University of Lübeck, 23538 Lübeck, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Lübeck, 23538 Lübeck</wicri:regionArea><wicri:noRegion>23538 Lübeck</wicri:noRegion><wicri:noRegion>23538 Lübeck</wicri:noRegion><wicri:noRegion>23538 Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Cushman, Mary" sort="Cushman, Mary" uniqKey="Cushman M" first="Mary" last="Cushman">Mary Cushman</name><affiliation wicri:level="2"><nlm:aff id="aff25">Departments of Medicine and Pathology, University of Vermont, Burlington, VT 05405, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Medicine and Pathology, University of Vermont, Burlington, VT 05405</wicri:regionArea><placeName><region type="state">Vermont</region></placeName></affiliation></author><author><name sortKey="Emilsson, Valur" sort="Emilsson, Valur" uniqKey="Emilsson V" first="Valur" last="Emilsson">Valur Emilsson</name><affiliation wicri:level="2"><nlm:aff id="aff26">Molecular Programming and Research Informatics, Merck & Co., Inc., Rahway, NJ 07065, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular Programming and Research Informatics, Merck & Co., Inc., Rahway, NJ 07065</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Plump, Andrew S" sort="Plump, Andrew S" uniqKey="Plump A" first="Andrew S." last="Plump">Andrew S. Plump</name><affiliation wicri:level="2"><nlm:aff id="aff27">Department of Cardiovascular Disease, Merck Research Laboratory, Rahway, NJ 07065, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cardiovascular Disease, Merck Research Laboratory, Rahway, NJ 07065</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Matijevic, Nena" sort="Matijevic, Nena" uniqKey="Matijevic N" first="Nena" last="Matijevic">Nena Matijevic</name><affiliation wicri:level="2"><nlm:aff id="aff28">Hemostasis Laboratory, University of Texas Health Science Center at Houston, Houston, TX 77030, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Hemostasis Laboratory, University of Texas Health Science Center at Houston, Houston, TX 77030</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Morange, Pierre Emmanuel" sort="Morange, Pierre Emmanuel" uniqKey="Morange P" first="Pierre-Emmanuel" last="Morange">Pierre-Emmanuel Morange</name><affiliation wicri:level="4"><nlm:aff id="aff29">INSERM, UMR_S 1062, Aix-Marseille Université, 13385 Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, UMR_S 1062, Aix-Marseille Université, 13385 Marseille</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J." last="Deary">Ian J. Deary</name><affiliation wicri:level="4"><nlm:aff id="aff4">Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff5">Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Hicks, Andrew A" sort="Hicks, Andrew A" uniqKey="Hicks A" first="Andrew A." last="Hicks">Andrew A. Hicks</name><affiliation wicri:level="1"><nlm:aff id="aff2">Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC); affiliated institute of the University of Lübeck, Lübeck, Germany), Viale Druso 1, 39100 Bolzano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC); affiliated institute of the University of Lübeck, Lübeck, Germany), Viale Druso 1, 39100 Bolzano</wicri:regionArea><wicri:noRegion>39100 Bolzano</wicri:noRegion></affiliation></author><author><name sortKey="Folsom, Aaron R" sort="Folsom, Aaron R" uniqKey="Folsom A" first="Aaron R." last="Folsom">Aaron R. Folsom</name><affiliation wicri:level="2"><nlm:aff id="aff1">Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55454, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55454</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author></analytic><series><title level="j">American Journal of Human Genetics</title><idno type="ISSN">0002-9297</idno><idno type="eISSN">1537-6605</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Activated partial thromboplastin time (aPTT) and prothrombin time (PT) are clinical tests commonly used to screen for coagulation-factor deficiencies. One genome-wide association study (GWAS) has been reported previously for aPTT, but no GWAS has been reported for PT. We conducted a GWAS and meta-analysis to identify genetic loci for aPTT and PT. The GWAS for aPTT was conducted in 9,240 individuals of European ancestry from the Atherosclerosis Risk in Communities (ARIC) study, and the GWAS for PT was conducted in 2,583 participants from the Genetic Study of Three Population Microisolates in South Tyrol (MICROS) and the Lothian Birth Cohorts (LBC) of 1921 and 1936. Replication was assessed in 1,041 to 3,467 individuals. For aPTT, previously reported associations with <italic>KNG1</italic>, <italic>HRG</italic>, <italic>F11</italic>, <italic>F12</italic>, and <italic>ABO</italic> were confirmed. A second independent association in <italic>ABO</italic> was identified and replicated (rs8176704, p = 4.26 × 10<sup>−24</sup>). Pooling the ARIC and replication data yielded two additional loci in <italic>F5</italic> (rs6028, p = 3.22 × 10<sup>−9</sup>) and <italic>AGBL1</italic> (rs2469184, p = 3.61 × 10<sup>−8</sup>). For PT, significant associations were identified and confirmed in <italic>F7</italic> (rs561241, p = 3.71 × 10<sup>−56</sup>) and <italic>PROCR/EDEM2</italic> (rs2295888, p = 5.25 × 10<sup>−13</sup>). Assessment of existing gene expression and coronary artery disease (CAD) databases identified associations of five of the GWAS loci with altered gene expression and two with CAD. In summary, eight genetic loci that account for ∼29% of the variance in aPTT and two loci that account for ∼14% of the variance in PT were detected and supported by functional data.</p></div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>France</li><li>Italie</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Maryland</li><li>Massachusetts</li><li>Minnesota</li><li>New Jersey</li><li>Provence-Alpes-Côte d'Azur</li><li>Texas</li><li>Vermont</li><li>Écosse</li></region><settlement><li>Glasgow</li><li>Marseille</li><li>Édimbourg</li></settlement><orgName><li>Université d'Aix-Marseille</li><li>Université d'Édimbourg</li><li>Université de Glasgow</li></orgName></list><tree><country name="États-Unis"><region name="Minnesota"><name sortKey="Tang, Weihong" sort="Tang, Weihong" uniqKey="Tang W" first="Weihong" last="Tang">Weihong Tang</name></region><name sortKey="Basu, Saonli" sort="Basu, Saonli" uniqKey="Basu S" first="Saonli" last="Basu">Saonli Basu</name><name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name><name sortKey="Cushman, Mary" sort="Cushman, Mary" uniqKey="Cushman M" first="Mary" last="Cushman">Mary Cushman</name><name sortKey="Emilsson, Valur" sort="Emilsson, Valur" uniqKey="Emilsson V" first="Valur" last="Emilsson">Valur Emilsson</name><name sortKey="Folsom, Aaron R" sort="Folsom, Aaron R" uniqKey="Folsom A" first="Aaron R." last="Folsom">Aaron R. Folsom</name><name sortKey="Johnson, Andrew D" sort="Johnson, Andrew D" uniqKey="Johnson A" first="Andrew D." last="Johnson">Andrew D. Johnson</name><name sortKey="Johnson, Andrew D" sort="Johnson, Andrew D" uniqKey="Johnson A" first="Andrew D." last="Johnson">Andrew D. Johnson</name><name sortKey="Johnson, Andrew D" sort="Johnson, Andrew D" uniqKey="Johnson A" first="Andrew D." last="Johnson">Andrew D. Johnson</name><name sortKey="Levy, Daniel" sort="Levy, Daniel" uniqKey="Levy D" first="Daniel" last="Levy">Daniel Levy</name><name sortKey="Matijevic, Nena" sort="Matijevic, Nena" uniqKey="Matijevic N" first="Nena" last="Matijevic">Nena Matijevic</name><name sortKey="Pankow, James S" sort="Pankow, James S" uniqKey="Pankow J" first="James S." last="Pankow">James S. Pankow</name><name sortKey="Plump, Andrew S" sort="Plump, Andrew S" uniqKey="Plump A" first="Andrew S." last="Plump">Andrew S. Plump</name><name sortKey="Tan, Adrian" sort="Tan, Adrian" uniqKey="Tan A" first="Adrian" last="Tan">Adrian Tan</name></country><country name="Italie"><noRegion><name sortKey="Schwienbacher, Christine" sort="Schwienbacher, Christine" uniqKey="Schwienbacher C" first="Christine" last="Schwienbacher">Christine Schwienbacher</name></noRegion><name sortKey="Gogele, Martin" sort="Gogele, Martin" uniqKey="Gogele M" first="Martin" last="Gögele">Martin Gögele</name><name sortKey="Hicks, Andrew A" sort="Hicks, Andrew A" uniqKey="Hicks A" first="Andrew A." last="Hicks">Andrew A. Hicks</name><name sortKey="Minelli, Cosetta" sort="Minelli, Cosetta" uniqKey="Minelli C" first="Cosetta" last="Minelli">Cosetta Minelli</name><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P." last="Pramstaller">Peter P. Pramstaller</name><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P." last="Pramstaller">Peter P. Pramstaller</name><name sortKey="Schwienbacher, Christine" sort="Schwienbacher, Christine" uniqKey="Schwienbacher C" first="Christine" last="Schwienbacher">Christine Schwienbacher</name><name sortKey="Volpato, Claudia B" sort="Volpato, Claudia B" uniqKey="Volpato C" first="Claudia B." last="Volpato">Claudia B. Volpato</name></country><country name="Royaume-Uni"><region name="Écosse"><name sortKey="Lopez, Lorna M" sort="Lopez, Lorna M" uniqKey="Lopez L" first="Lorna M." last="Lopez">Lorna M. Lopez</name></region><name sortKey="Ben Shlomo, Yoav" sort="Ben Shlomo, Yoav" uniqKey="Ben Shlomo Y" first="Yoav" last="Ben-Shlomo">Yoav Ben-Shlomo</name><name sortKey="Davies, Gail" sort="Davies, Gail" uniqKey="Davies G" first="Gail" last="Davies">Gail Davies</name><name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J." last="Deary">Ian J. Deary</name><name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J." last="Deary">Ian J. Deary</name><name sortKey="Gallacher, John" sort="Gallacher, John" uniqKey="Gallacher J" first="John" last="Gallacher">John Gallacher</name><name sortKey="Gow, Alan J" sort="Gow, Alan J" uniqKey="Gow A" first="Alan J." last="Gow">Alan J. Gow</name><name sortKey="Gow, Alan J" sort="Gow, Alan J" uniqKey="Gow A" first="Alan J." last="Gow">Alan J. Gow</name><name sortKey="Lopez, Lorna M" sort="Lopez, Lorna M" uniqKey="Lopez L" first="Lorna M." last="Lopez">Lorna M. Lopez</name><name sortKey="Lowe, Gordon D O" sort="Lowe, Gordon D O" uniqKey="Lowe G" first="Gordon D. O." last="Lowe">Gordon D. O. Lowe</name><name sortKey="Porteous, David J" sort="Porteous, David J" uniqKey="Porteous D" first="David J." last="Porteous">David J. Porteous</name><name sortKey="Porteous, David J" sort="Porteous, David J" uniqKey="Porteous D" first="David J." last="Porteous">David J. Porteous</name><name sortKey="Rumley, Ann" sort="Rumley, Ann" uniqKey="Rumley A" first="Ann" last="Rumley">Ann Rumley</name><name sortKey="Samani, Nilesh J" sort="Samani, Nilesh J" uniqKey="Samani N" first="Nilesh J." last="Samani">Nilesh J. Samani</name><name sortKey="Samani, Nilesh J" sort="Samani, Nilesh J" uniqKey="Samani N" first="Nilesh J." last="Samani">Nilesh J. Samani</name><name sortKey="Starr, John M" sort="Starr, John M" uniqKey="Starr J" first="John M." last="Starr">John M. Starr</name><name sortKey="Starr, John M" sort="Starr, John M" uniqKey="Starr J" first="John M." last="Starr">John M. Starr</name><name sortKey="Tenesa, Albert" sort="Tenesa, Albert" uniqKey="Tenesa A" first="Albert" last="Tenesa">Albert Tenesa</name><name sortKey="Tenesa, Albert" sort="Tenesa, Albert" uniqKey="Tenesa A" first="Albert" last="Tenesa">Albert Tenesa</name><name sortKey="Yarnell, John W G" sort="Yarnell, John W G" uniqKey="Yarnell J" first="John W. G." last="Yarnell">John W. G. Yarnell</name></country><country name="France"><noRegion><name sortKey="Oudot Mellakh, Tiphaine" sort="Oudot Mellakh, Tiphaine" uniqKey="Oudot Mellakh T" first="Tiphaine" last="Oudot-Mellakh">Tiphaine Oudot-Mellakh</name></noRegion><name sortKey="Morange, Pierre Emmanuel" sort="Morange, Pierre Emmanuel" uniqKey="Morange P" first="Pierre-Emmanuel" last="Morange">Pierre-Emmanuel Morange</name><name sortKey="Tregouet, David Alexandre" sort="Tregouet, David Alexandre" uniqKey="Tregouet D" first="David-Alexandre" last="Tregouet">David-Alexandre Tregouet</name></country><country name="Australie"><noRegion><name sortKey="Visscher, Peter M" sort="Visscher, Peter M" uniqKey="Visscher P" first="Peter M." last="Visscher">Peter M. Visscher</name></noRegion></country><country name="Allemagne"><noRegion><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P." last="Pramstaller">Peter P. 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